Preprints

Koutsoumpari N, Algermissen J, Yaakub S, den Ouden HEM, Bault N, Fouragnan E (2025). Ultrasound neuromodulation reveals distinct roles of the dorsal anterior cingulate cortex and anterior insula in Pavlovian biases. bioRxiv Preprint

Scholz V, Algermissen J, Kandroodi MR, Gillan C, den Ouden HEM (2025). Adaptive suppression of motivational biases increases with mood/anxiety traits. psyArXiv Preprint

2025

Kop BR, de Jong L., Kim BP, den Ouden HEM, Verhagen L (2025). Parameter optimisation for mitigating somatosensory confounds during transcranial ultrasonic stimulation. Brain stimulation, 18(4), 1224–1236. pdf; data and analysis code.

Schepers M, Lagerweij P, Geurts D, Krause F, den Ouden HEM, Cools R, Speckens A, Collin G (2025). Promoting Resilience in Youth through Mindfulness mEditation (PRYME): Study protocol for a randomized controlled trial investigating the effects of mindfulness training as add-on to care-as-usual on internalizing problems, mental illness development, and associated brain and cognitive processes in help-seeking youth. BMC psychiatry, 25(1), 126. pdf.

2024

Geurts DEM*, den Ouden HEM*, Swart JC, Froböse MI, Fallon SJ, Cook J, Cools R (2024). Methylphenidate enhances or impairs the cognitive control of Pavlovian bias depending on working memory capacity. eLife. pdf.

Koolschijn R, Polner B, Hoomans JM, Cools R, Vassena E, den Ouden HEM (2024). Resources, costs and long-term value: an integrative perspective on serotonin and meta-decision making. Current Opinion in Behavioral Sciences, 60. pdf.

Algermissen, J, den Ouden, HEM (2024). High stakes slow responding, but do not help overcome Pavlovian biases in humans. Learning & Memory, 31(8). pdf; supplementary material; analysis code, task code, raw data, and results; code on Github; permanent copy of code on Github.

Algermissen J, den Ouden HEM (2024). Pupil dilation reflects effortful action invigoration in overcoming aversive Pavlovian biases. Cognitive Affective Behavioral Neuroscience. pdf; data; code on GitHub; pre-registration.

Algermissen J, Swart JC, Scheeringa R, Cools R, den Ouden HEM (2023). Prefrontal signals precede striatal signals for biased credit assignment in motivational learning biases. Nature Communications. pdf; raw data; preprocessed data and results; code; code on Github; permanent copy of code on Github.

2023

Algermissen J, den Ouden HEM (2023). Goal-directed recruitment of Pavlovian biases through selective visual attention. Journal of Experimental Psychology: General, 152(10), 2941–2956. pdf; data, analysis code, and research materials; code on Github; permanent copy of code on Github.

Chen P, Geurts DEM, Määttä JI, van den Bosch R, Hofmans L, Papadopetraki D, den Ouden HEM, Cools R (2023). Effect of striatal dopamine on Pavlovian bias. A large [¹⁸F]-DOPA PET study. Behavioral neuroscience, 137(3), 184–195. pdf; data and analysis code.

Kop BR, Shamli Oghli Y, Grippe TC, Nandi T, Lefkes J, Meijer SW, Farboud S, Engels M, Hamani M, Null M, Radetz A, Hassan U, Darmani G, Chetverikov A, den Ouden HEM, Bergmann TO, Chen R, Verhagen L (2023). Auditory confounds can drive online effects of transcranial ultrasonic stimulation in humans. eLife. pdf; data and analysis code.

2022

Kanen J, Luo Q, Rostami Kandroodi M, Cardinal R, Robbins TW, Nutt D, Carhart-Harris R, den Ouden HEM. (2022). Effect of lysergic acid diethylamide (LSD) on reinforcement learning in humans. Psychological Medicine, 1-12. pdf; supplementary material.

Geurts DEM, den Ouden HEM, Janssen L, Swart JC, Froböse MI, Cools R, Speckens AEM (2022). Aversive Pavlovian inhibition in adult attention-deficit/hyperactivity disorder and its restoration by mindfulness-based cognitive therapy. Frontiers in Behavioral Neuroscience. pdf; supplementary material.

Scholz V, Hook RW, Kandroodi MR, Algermissen J, Ioannidis K, Christmas D, Valle S, Robbins TW, Grant JE, Chamberlain SR, den Ouden HEM (2022). Cortical dopamine reduces the impact of motivational biases governing automated behaviour. Neuropsychopharmacology. pdf; supplementary material.

Brolsma SCA, Vrijsen, JN, Vassena E, Rostami Kandroodi M, Bergman MA, van Eijndhoven PF, Collard RM, den Ouden HEM, Schene AH, Cools R (2022). Challenging the negative learning bias hypothesis of depression: reversal learning in a naturalistic psychiatric sample. Psychological medicine, 52(2), 303–313. pdf; supplementary material.

2021

Algermissen J, Swart JC, Scheeringa R, Cools R, den Ouden HEM (2021). Striatal BOLD and midfrontal theta power express motivation for action. Cerebral Cortex. pdf; supplementary material; raw data; code, preprocessed data, and results; code on Github; permanent copy of code.

Rostami Kandroodi M, Cook JL, Swart JC, Froböse MI, Geurts DEM, Vahabie A, Ahmadabadi MN, Cools R, den Ouden HEM (2021). Effects of methylphenidate on reversal learning depend on working memory capacity. Psychopharmacology. pdf; supplementary material.

2020

van Nuland AJ, Helmich RC, Dirkx MF, Zach H, Toni I, Cools R, den Ouden HEM (2020). Effects of dopamine on reinforcement learning in Parkinson’s disease depend on motor phenotype. Brain, 143(11). pdf; supplementary material.

van Nuland AJ, den Ouden HEM, Zach H, Dirkx MF, van Asten JJ, Scheenen TW, Toni, I, Cools, R, Helmich RC (2020). GABAergic changes in the thalamocortical circuit in Parkinson's disease. Human brain mapping, 41(4). pdf; supplementary material.

Crawley D, Zhang L, Jones EJ, Ahmad J, Oakley B, San José Cáceres A, Charman T, Buitelaar JK, Murphy DGM, Chatham C, den Ouden HEM*, Loth E* & EU-AIMS LEAP group (2020). Modeling flexible behavior in childhood to adulthood shows age-dependent learning mechanisms and less optimal learning in autism in each age group. PLoS Biology, 18(10). pdf.

2019

Millner AJ, den Ouden HEM, Gershman SJ, Glenn CR, Kearns JC, Bornstein AM, Marx BP, Keane TM, Nock MK (2019). Suicidal thoughts and behaviors are associated with an increased decision-making bias for active responses to escape aversive states. Journal of abnormal psychology.

Cook JL, Swart JC, Froböse MI, Diaconescu AO, Geurts DEM, Den Ouden HEM, Cools R (2019). Catecholaminergic modulation of meta-learning. Elife, 8. pdf; data and analysis code.

2018

Swart JC, Frank MJ, Määttä JI, Jensen O, Cools R, den Ouden HEM (2018). Frontal network dynamics reflect neurocomputational mechanisms for reducing maladaptive biases in motivated action. PLoS biology, 16(10). pdf; data, task and analysis code.

Millner AJ, Gershman SJ, Nock MK, den Ouden HEM (2018). Pavlovian control of escape and avoidance. Journal of Cognitive Neuroscience, 30(10). pdf.

Cools R, den Ouden HEM, Huys QJM (2008). How do emotions and cognition interact? In Fox AS, Lapate, RC, Shackman AJ & Davidson RJ (Eds.), The nature of emotion: Fundamental questions. Oxford University Press. pdf.

2017

Swart JC, Froböse MI, Cook JL, Geurts DEM, Frank MJ, Cools R*, den Ouden HEM* (2017). Catecholaminergic challenge uncovers distinct Pavlovian and instrumental mechanisms of motivated (in) action. Elife, 6. pdf; analysis code; observed and simulated source data.

Dirkx MF, den Ouden HEM, Aarts E, Timmer MH, Bloem BR, Toni I, Helmich RC (2017). Dopamine controls Parkinson’s tremor by inhibiting the cerebellar thalamus. Brain, 140(3). pdf; supplementary material.

Piray P, den Ouden HEM, van der Schaaf ME, Toni I, Cools R (2017). Dopaminergic modulation of the functional ventrodorsal architecture of the human striatum. Cerebral Cortex, 27(1). pdf; supplementary material.

2016

Dirkx MF, den Ouden HEM, Aarts E, Timmer M, Bloem BR, Toni I, Helmich RC. (2016). The cerebral network of Parkinson's tremor: an effective connectivity fMRI study. Journal of Neuroscience, 36(19). pdf.

Kroes MC, Tona KD, den Ouden HEM, Vogel S, van Wingen GA, Fernández G (2016). How administration of the beta-blocker propranolol before extinction can prevent the return of fear. Neuropsychopharmacology, 41(6). pdf.

Heinzle J, Koopmans PJ, den Ouden HEM, Raman S, Stephan KE (2016). A hemodynamic model for layered BOLD signals. Neuroimage, 125. pdf.

2015

den Ouden HEM, Swart JC, Schmidt K, Fekkes D, Geurts DEM, Cools R (2015). Acute serotonin depletion releases motivated inhibition of response vigour. Psychopharmacology, 232(7). pdf.

Sjoerds Z, den Ouden HEM (2015). Computationele psychiatrie: een toekomst voor wiskundige modellen in de classificatie en behandeling van psychopathologie? Neuropraxis, 19(6). pdf.

van Schouwenburg MR, den Ouden HEM, Cools R (2015). Selective attentional enhancement and inhibition of fronto-posterior connectivity by the basal ganglia during attention switching. Cerebral Cortex, 25(6). pdf.

2014

Cook JL, Den Ouden HEM, Heyes CM, Cools R (2014). The social dominance paradox. Current Biology, 24(23). pdf.

2013

den Ouden HEM, Daw ND, Fernandez G, Elshout JA, Rijpkema M, Hoogman M, Franke B, Cools R (2013). Dissociable effects of dopamine and serotonin on reversal learning. Neuron, 80(4). pdf.

Sescousse G*, den Ouden HEM* (2013). Gambling rats and gambling addiction: reconciling the role of dopamine in irrationality. Journal of Neuroscience, 33(8). pdf.

Iglesias S, Mathys C, Brodersen KH, Kasper L, Piccirelli M, den Ouden HEM, Stephan KE (2013). Hierarchical prediction errors in midbrain and basal forebrain during sensory learning. Neuron, 80(2). pdf. 

Geurts DEM, Huys QJ, den Ouden HEM, Cools R (2013). Serotonin and aversive Pavlovian control of instrumental behavior in humans. Journal of Neuroscience, 33(48). pdf.

Geurts DEM, Huys QJ, den Ouden HEM, Cools R (2013). Aversive Pavlovian control of instrumental behavior in humans. Journal of cognitive neuroscience, 25(9). pdf.

Volman I, Verhagen L, den Ouden HEM, Fernández G, Rijpkema M, Franke B, Toni I, Roelofs K (2013). Reduced serotonin transporter availability decreases prefrontal control of the amygdala. Journal of Neuroscience, 33(21). pdf.

2012

den Ouden HEM, Kok P, De Lange FP (2012). How prediction errors shape perception, attention, and motivation. Frontiers in psychology, 3. pdf.

Crockett MJ, Clark L, Roiser JP, Robinson OJ, Cools R, Chase HW, den Ouden HEM, Apergis-Schoute A, Campbell-Meiklejohn D, Seymour B, Sahakian BJ, Rogers RD, Robbins TW (2012). Converging evidence for central 5-HT effects in acute tryptophan depletion. Molecular psychiatry, 17(2). pdf

2011

Van Leeuwen TM, den Ouden HEM, Hagoort P (2011). Effective connectivity determines the nature of subjective experience in grapheme-color synesthesia. Journal of Neuroscience, 31(27). pdf.

2010

den Ouden HEM, Daunizeau J, Roiser J, Friston KJ, Stephan KE (2010). Striatal prediction error modulates cortical coupling. Journal of Neuroscience, 30(9). pdf.

van Schouwenburg MR, den Ouden HEM, Cools R (2010). The human basal ganglia modulate frontal-posterior connectivity during attention shifting. Journal of Neuroscience, 30(29). pdf.

Daunizeau J, den Ouden HEM, Pessiglione M, Kiebel SJ, Stephan KE, Friston KJ (2010). Observing the observer (I): meta-bayesian models of learning and decision-making. PloS one, 5(12). pdf.

Daunizeau J, den Ouden HEM, Pessiglione M, Kiebel SJ, Friston KJ, Stephan KE (2010). Observing the observer (II): deciding when to decide. PLoS one, 5(12). pdf.

Roiser JP, Stephan KE, den Ouden HEM, Friston KJ, Joyce EM (2010). Adaptive and aberrant reward prediction signals in the human brain. Neuroimage, 50(2). pdf.

Stephan KE, Penny WD, Moran RJ, den Ouden HEM, Daunizeau J, Friston KJ (2010). Ten simple rules for dynamic causal modeling. Neuroimage, 49(4). pdf.

2009

den Ouden HEM, Friston KJ, Daw ND, McIntosh AR, Stephan KE (2009). A dual role for prediction error in associative learning. Cerebral cortex, 19(5). pdf.

Roiser JP, Stephan KE, Den Ouden, HEM, Barnes TRE, Friston KJ, Joyce EM (2009). Do patients with schizophrenia exhibit aberrant salience?. Psychological medicine, 39(2). pdf.

Prior to 2009

Stephan KE, Kasper L, Harrison LM, Daunizeau J, den Ouden HEM, Breakspear M, Friston KJ (2008). Nonlinear dynamic causal models for fMRI. Neuroimage, 42(2). pdf.

Blakemore SJ, den Ouden HEM, Choudhury S, Frith C (2007). Adolescent development of the neural circuitry for thinking about intentions. Social cognitive and affective neuroscience, 2(2). pdf.

den Ouden HEM, Frith U, Frith C, Blakemore SJ (2005). Thinking about intentions. Neuroimage, 28(4). pdf.

den Ouden HEM, Van Ee R, De Haan EHF (2005). Colour helps to solve the binocular matching problem. The Journal of Physiology, 567(2). pdf.