Papers
Preprints
Scholz V, Algermissen J, Kandroodi MR, Gillan C, den Ouden HEM (2025). Adaptive suppression of motivational biases increases with mood/anxiety traits. PsyArXiv Preprint
2025
Schepers M, Lagerweij P, Geurts D, Krause F, den Ouden HEM, Cools R, Speckens A, Collin G (2025). Promoting Resilience in Youth through Mindfulness mEditation (PRYME): Study protocol for a randomized controlled trial investigating the effects of mindfulness training as add-on to care-as-usual on internalizing problems, mental illness development, and associated brain and cognitive processes in help-seeking youth. pdf.
2024
Geurts DEM*, den Ouden HEM*, Swart JC, Froböse MI, Fallon SJ, Cook J Cools R (2024). Methylphenidate enhances or impairs the cognitive control of Pavlovian bias depending on working memory capacity. eLife preprint. pdf.
Koolschijn R, Polner B, Hoomans JM, Cools R, Vassena E den Ouden HEM (2024). Resources, costs and long-term value: an integrative perspective on serotonin and meta-decision making, 60. Current Opinion in Behavioral Sciences; pdf.
Algermissen, J, den Ouden, HEM (2024). High stakes slow responding, but do not help overcome Pavlovian biases in humans. Learning & Memory, 31(8); pdf; supplementary material; analysis code, task code, raw data, and results; code on Github; permanent copy of code on Github.
Algermissen J, den Ouden HEM (2024). Pupil dilation reflects effortful action invigoration in overcoming aversive Pavlovian biases. Cognitive Affective Behavioral Neuroscience; pdf; data; code on GitHub; pre-registration.
Algermissen J, Swart JC, Scheeringa R, Cools R, den Ouden HEM (2023). Prefrontal signals precede striatal signals for biased credit assignment in motivational learning biases. Nature Communications; pdf; raw data; preprocessed data and results; code; code on Github; permanent copy of code on Github.
2023
Algermissen J, & den Ouden HEM (2023). Goal-directed recruitment of Pavlovian biases through selective visual attention. Journal of Experimental Psychology: General, 152(10), 2941–2956. pdf; data, analysis code, and research materials; code on Github; permanent copy of code on Github.
Chen P, Geurts DEM, Määttä JI, van den Bosch R, Hofmans L, Papadopetraki D, den Ouden HEM, Cools R (2023). Effect of striatal dopamine on Pavlovian bias. A large [¹⁸F]-DOPA PET study. Behavioral neuroscience, 137(3), 184–195. pdf.
Kop BR, Shamli Oghli Y, Grippe TC, Nandi T, Lefkes J, Meijer SW, Farboud S, Engels M, Hamani M, Null M, Radetz A, Hassan U, Darmani G, Chetverikov A, den Ouden HEM, Bergmann TO, ChenR, Verhagen L (2023). Auditory confounds can drive online effects of transcranial ultrasonic stimulation in humans. eLife; pdf; data and analysis code.
2022
Kanen J, Luo Q, Rostami Kandroodi M, Cardinal R, Robbins TW, Nutt D, Carhart-Harris R, den Ouden HEM. (2022). Effect of lysergic acid diethylamide (LSD) on reinforcement learning in humans. Psychological Medicine, 1-12. pdf. supplementary material
Geurts DEM, den Ouden HEM, Janssen L, Swart JC, Froböse MI, Cools R, Speckens AEM (2022) Aversive Pavlovian inhibition in adult attention-deficit/hyperactivity disorder and its restoration by mindfulness-based cognitive therapy. Frontiers in Behavioral Neuroscience. pdf;
Scholz V, Hook RW, Kandroodi MR, Algermissen J, Ioannidis K, Christmas D, Valle S, Robbins TW, Grant JE, Chamberlain SR, den Ouden HEM (2022). Cortical dopamine reduces the impact of motivational biases governing automated behaviour. Neuropsychopharmacology. pdf; supplementary material
Brolsma SCA, Vrijsen, JN, Vassena E, Rostami Kandroodi M, Bergman MA, van Eijndhoven PF, Collard RM, den Ouden HEM, Schene AH, Cools R (2022). Challenging the negative learning bias hypothesis of depression: reversal learning in a naturalistic psychiatric sample. Psychological medicine, 52(2), 303–313. pdf.
2021
Algermissen J, Swart JC, Scheeringa R, Cools R, den Ouden HE (2021). Striatal BOLD and midfrontal theta power express motivation for action. Cerebral Cortex. pdf; supplementary material; raw data; code, preprocessed data, and results; code on Github; permanent copy of code.
Rostami Kandroodi M, Cook JL, Swart JC, Froböse MI, Geurts DEM, Vahabie A, Ahmadabadi MN, Cools R, den Ouden HEM (2021). Effects of methylphenidate on reversal learning depend on working memory capacity. Psychopharmacology. pdf; supplementary material
2020
van Nuland AJ, Helmich RC, Dirkx MF, Zach H, Toni I, Cools R, den Ouden HE (2020). Effects of dopamine on reinforcement learning in Parkinson’s disease depend on motor phenotype. Brain, 143(11). pdf
van Nuland AJ, den Ouden HE, Zach H, Dirkx MF, van Asten JJ, Scheenen TW, Toni, I, Cools, R, Helmich RC (2020). GABAergic changes in the thalamocortical circuit in Parkinson's disease. Human brain mapping, 41(4). pdf
Crawley D, Zhang L, Jones EJ, Ahmad J, Oakley B, San José Cáceres A, Charman T, Buitelaar JK, Murphy DGM, Chatham C, den Ouden HEM*, Loth E* & EU-AIMS LEAP group. (2020). Modeling flexible behavior in childhood to adulthood shows age-dependent learning mechanisms and less optimal learning in autism in each age group. PLoS Biology, 18(10). pdf
2019
Millner AJ, den Ouden HEM, Gershman SJ, Glenn CR, Kearns JC, Bornstein AM, Marx BP, Keane TM, Nock MK (2019). Suicidal thoughts and behaviors are associated with an increased decision-making bias for active responses to escape aversive states. Journal of abnormal psychology.
Cook JL, Swart JC, Froböse MI, Diaconescu AO, Geurts DEM, Den Ouden HEM, Cools R (2019). Catecholaminergic modulation of meta-learning. Elife, 8. pdf
2018
Swart, J. C., Frank, M. J., Määttä, J. I., Jensen, O., Cools, R., den Ouden, H. E. (2018). Frontal network dynamics reflect neurocomputational mechanisms for reducing maladaptive biases in motivated action. PLoS biology, 16(10). pdf
Millner, A. J., Gershman, S. J., Nock, M. K., den Ouden, H. E. (2018). Pavlovian control of escape and avoidance. Journal of Cognitive Neuroscience, 30(10). pdf
Cools R., den Ouden H.E.M., Huys Q.J.M. (2008). How do emotions and cognition interact? In Fox, A. S., Lapate, R. C., Shackman, A. J., & Davidson, R. J. (Eds.), The nature of emotion: Fundamental questions. Oxford University Press.
2017
Swart, J. C., Froböse, M. I., Cook, J. L., Geurts, D. E., Frank, M. J., Cools, R.*, den Ouden, H. E.* (2017). Catecholaminergic challenge uncovers distinct Pavlovian and instrumental mechanisms of motivated (in) action. Elife, 6. pdf
Dirkx, M. F., den Ouden, H. E., Aarts, E., Timmer, M. H., Bloem, B. R., Toni, I., Helmich, R. C. (2017). Dopamine controls Parkinson’s tremor by inhibiting the cerebellar thalamus. Brain, 140(3). pdf
Piray, P., den Ouden, H. E., van der Schaaf, M. E., Toni, I., Cools, R. (2017). Dopaminergic modulation of the functional ventrodorsal architecture of the human striatum. Cerebral Cortex, 27(1). pdf
2016
Dirkx, M. F., den Ouden HEM, Aarts, E., Timmer, M., Bloem, B. R., Toni, I., Helmich, R. C. (2016). The cerebral network of Parkinson's tremor: an effective connectivity fMRI study. Journal of Neuroscience, 36(19). pdf
Kroes, M. C., Tona, K. D., den Ouden, H. E., Vogel, S., van Wingen, G. A., Fernández, G. (2016). How administration of the beta-blocker propranolol before extinction can prevent the return of fear. Neuropsychopharmacology, 41(6). pdf
Heinzle, J., Koopmans, P. J., den Ouden, H. E., Raman, S., & Stephan, K. E. (2016). A hemodynamic model for layered BOLD signals. Neuroimage, 125. pdf
2015
den Ouden, H. E., Swart, J. C., Schmidt, K., Fekkes, D., Geurts, D. E., Cools, R. (2015). Acute serotonin depletion releases motivated inhibition of response vigour. Psychopharmacology, 232(7). pdf
Sjoerds, Z., & den Ouden, H. E. (2015). Computationele psychiatrie: een toekomst voor wiskundige modellen in de classificatie en behandeling van psychopathologie?. Neuropraxis, 19(6). pdf
van Schouwenburg, M. R., den Ouden, HEM Cools, R. (2015). Selective attentional enhancement and inhibition of fronto-posterior connectivity by the basal ganglia during attention switching. Cerebral Cortex, 25(6). pdf
2014
Cook, J. L., Den Ouden, H. E., Heyes, C. M., & Cools, R. (2014). The social dominance paradox. Current Biology, 24(23). pdf
2013
den Ouden, H. E., Daw, N. D., Fernandez, G., Elshout, J. A., Rijpkema, M., Hoogman, M., ... & Cools, R. (2013). Dissociable effects of dopamine and serotonin on reversal learning. Neuron, 80(4). pdf
Sescousse, G.*, & den Ouden, H. E.* (2013). Gambling rats and gambling addiction: reconciling the role of dopamine in irrationality. Journal of Neuroscience, 33(8). pdf
Iglesias, S., Mathys, C., Brodersen, K. H., Kasper, L., Piccirelli, M., den Ouden, H. E., & Stephan, K. E. (2013). Hierarchical prediction errors in midbrain and basal forebrain during sensory learning. Neuron, 80(2). pdf
Geurts, D. E., Huys, Q. J., den Ouden, H. E., & Cools, R. (2013). Serotonin and aversive Pavlovian control of instrumental behavior in humans. Journal of Neuroscience, 33(48). pdf
Geurts, D. E., Huys, Q. J., den Ouden, H. E., & Cools, R. (2013). Aversive Pavlovian control of instrumental behavior in humans. Journal of cognitive neuroscience, 25(9). pdf
Volman, I., Verhagen, L., den Ouden, H. E., Fernández, G., Rijpkema, M., Franke, B., ... & Roelofs, K. (2013). Reduced serotonin transporter availability decreases prefrontal control of the amygdala. Journal of Neuroscience, 33(21). pdf
2012
den Ouden, H. E., Kok, P., & De Lange, F. P. (2012). How prediction errors shape perception, attention, and motivation. Frontiers in psychology, 3. pdf
Crockett, M. J., Clark, L., Roiser, J. P., Robinson, O. J., Cools, R., Chase, H. W., ... & Robbins, T. W. (2012). Converging evidence for central 5-HT effects in acute tryptophan depletion. Molecular psychiatry, 17(2). pdf
2011
Van Leeuwen, T. M., Den Ouden, H. E., & Hagoort, P. (2011). Effective connectivity determines the nature of subjective experience in grapheme-color synesthesia. Journal of Neuroscience, 31(27). pdf
2010
den Ouden, H. E., Daunizeau, J., Roiser, J., Friston, K. J., & Stephan, K. E. (2010). Striatal prediction error modulates cortical coupling. Journal of Neuroscience, 30(9). pdf
van Schouwenburg, M. R., den Ouden, H. E., & Cools, R. (2010). The human basal ganglia modulate frontal-posterior connectivity during attention shifting. Journal of Neuroscience, 30(29). pdf
Daunizeau, J., Den Ouden, H. E., Pessiglione, M., Kiebel, S. J., Stephan, K. E., & Friston, K. J. (2010). Observing the observer (I): meta-bayesian models of learning and decision-making. PloS one, 5(12). pdf
Daunizeau, J., Den Ouden, H. E., Pessiglione, M., Kiebel, S. J., Friston, K. J., & Stephan, K. E. (2010). Observing the observer (II): deciding when to decide. PLoS one, 5(12). pdf
Roiser, J. P., Stephan, K. E., den Ouden, H. E., Friston, K. J., & Joyce, E. M. (2010). Adaptive and aberrant reward prediction signals in the human brain. Neuroimage, 50(2). pdf
Stephan, K. E., Penny, W. D., Moran, R. J., den Ouden, H. E., Daunizeau, J., & Friston, K. J. (2010). Ten simple rules for dynamic causal modeling. Neuroimage, 49(4). pdf
2009
den Ouden, H. E., Friston, K. J., Daw, N. D., McIntosh, A. R., & Stephan, K. E. (2009). A dual role for prediction error in associative learning. Cerebral cortex, 19(5). pdf
Roiser, J. P., Stephan, K. E., Den Ouden, HEM, Barnes, T. R. E., Friston, K. J., & Joyce, E. M. (2009). Do patients with schizophrenia exhibit aberrant salience?. Psychological medicine, 39(2). pdf
Prior to 2009
Stephan, K. E., Kasper, L., Harrison, L. M., Daunizeau, J., den Ouden, H. E., Breakspear, M., & Friston, K. J. (2008). Nonlinear dynamic causal models for fMRI. Neuroimage, 42(2). pdf
Blakemore, S. J., den Ouden, H., Choudhury, S., & Frith, C. (2007). Adolescent development of the neural circuitry for thinking about intentions. Social cognitive and affective neuroscience, 2(2). pdf
den Ouden HEM, Frith, U., Frith, C., & Blakemore, S. J. (2005). Thinking about intentions. Neuroimage, 28(4). pdf
den Ouden, HEM, Van Ee, R., & De Haan, E. H. F. (2005). Colour helps to solve the binocular matching problem. The Journal of Physiology, 567(2). pdf